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Our research focuses on immune regulatory mechanisms in autoimmune diseases. 

Our main research is to assess the role of the Semaphorin family found to be highly important in regulating the immune system, both the adaptive and innate immunity.

In previuos studies we reported on the decreased serum level of semaphorin3A and its expression on both T regulatory and B regulatory cells mainly in SLE, Scleroderma and Allergy.

In animal models of SLE and asthma we demonstrated the beneficial effect of injecting recombinant semphorin3A to these mice.

One additional field of interest is of chronic spontinious urticaria (CSU), we run histophatological studies aiming to understand skin pathopysiology of CSU mainly the autoimmine origin of this disease. we are also engaged with clinical/theraputic studies aiming to improve the outcome of severe CSU. 

Our research is translational and innovative

Our Lab is located at the Bnai-Zion Medical Center, Haifa and at the Rappaport faculty of medicine, Technion , Haifa. 


1: Toubi E, Vadasz Z. Innate immune-responses and their role in driving autoimmunity. Autoimmun Rev. 2019 Jan 11. pii: S15689972(19)30011-4. doi:10.1016/j.autrev.2018.10.005. [Epub ahead of print] Review. PubMed PMID:30639645.


2: Sabag AD, Dias-Polak D, Bejar J, Sheffer H, Bergman R, Vadasz Z. Altered expression of regulatory molecules in the skin of psoriasis. Immunol Res. 2019 Jan 7. doi: 10.1007/s12026-018-9057-9. [Epub ahead of print] PubMed PMID: 30613859.

3: Toubi E, Vadasz Z. Updates in Rheumatology and Autoimmunity in the Israel Medical Association Journal (IMAJ) 2018. Isr Med Assoc J. 2018 Oct;20(10):645-648. Review. PubMed PMID: 30324784.

4: Lavi N, Kessler O, Ziv K, Nir-Zvi I, Mumblat Y, Eiza N, Paran Y, Brenner B, Vadasz Z, Neufeld G. Semaphorin-3A inhibits multiple myeloma progression in a mouse model. Carcinogenesis. 2018 Oct 8;39(10):1283-1291. doi: 10.1093/carcin/bgy106. PubMed PMID: 30102336.

5: Levy I, Vadasz Z, Polliack A, Tadmor T. The Frequency and Prognostic Value of  Neutrophilia in Chronic Lymphocytic Leukemia. Anticancer Res. 2018 Aug;38(8):4731-4734. doi: 10.21873/anticanres.12780. PubMed PMID: 30061242.

6: Vadasz Z, Toubi E. Hemostasis in Allergy. Semin Thromb Hemost. 2018 Oct;44(7):669-675. doi: 10.1055/s-0038-1648232. Epub 2018 Jun 19. Review. PubMed PMID: 29920622.

7: Bejar J, Kessler O, Sabag AD, Sabo E, Itzhak OB, Neufeld G, Vadasz Z. Semaphorin3A: A Potential Therapeutic Tool for Lupus Nephritis. Front Immunol. 2018 Apr 4;9:634. doi: 10.3389/fimmu.2018.00634. eCollection 2018. PubMed PMID: 29670620; PubMed Central PMCID: PMC5893899.

8: Eiza N, Zuckerman E, Carlebach M, Rainis T, Goldberg Y, Vadasz Z. Increased killer B cells in chronic HCV infection may lead to autoimmunity and increased viral load. Clin Exp Immunol. 2018 Aug;193(2):183-193. doi: 10.1111/cei.13139. PubMed PMID: 29665000; PubMed Central PMCID: PMC6046472.

9: Vadasz Z, Toubi E. Semaphorin3A: A potential therapeutic tool in immune-mediated diseases. Eur J Rheumatol. 2018 Mar;5(1):58-61. doi: 10.5152/eurjrheum.2017.17076. Epub 2017 Dec 7. Review. PubMed PMID: 29657877; PubMed Central PMCID: PMC5895154.

10: Tadmor T, Levy I, Vadasz Z. Hierarchical Involvement of Myeloid-Derived Suppressor Cells and Monocytes Expressing Latency-Associated Peptide in Plasma Cell Dyscrasias. Turk J Haematol. 2018 May 25;35(2):116-121. doi: 10.4274/tjh.2018.0022. Epub 2018 Mar 28. PubMed PMID: 29589834; PubMed Central PMCID: PMC5972333.

11: Willner N, Goldberg Y, Schiff E, Vadasz Z. Semaphorin 4D levels in heart failure patients: a potential novel biomarker of acute heart failure? ESC Heart Fail. 2018 Aug;5(4):603-609. doi: 10.1002/ehf2.12275. Epub 2018 Mar 10. PubMed PMID: 29524314; PubMed Central PMCID: PMC6073021.

12: Vadasz Z, Rubinstein J, Bejar J, Sheffer H, Halachmi S. Overexpression of semaphorin 3A in patients with urothelial cancer. Urol Oncol. 2018 Apr;36(4):161.e1-161.e6. doi: 10.1016/j.urolonc.2017.12.007. Epub 2017 Dec 27. PubMed PMID: 29288007.

13: Vadasz Z. Rheumatology and Autoimmunity in The Israel Medical Association Journal (IMAJ): 2017. Isr Med Assoc J. 2017 Dec;19(12):781-783. PubMed PMID: 29235744.

14: Vadasz Z, Tal Y, Rotem M, Shichter-Confino V, Mahlab-Guri K, Graif Y, Kessel  A, Agmon-Levin N, Maoz-Segal R, Kivity S, Benor S, Lachover-Roth I, Zeldin Y, Stein M, Toker O, Hassoun G, Bezalel-Rosenberg S, Toubi E, Asher I, Sthoeger Z; Israeli Forum for investigating and treating Chronic Spontaneous Urticaria (CSU). Omalizumab for severe chronic spontaneous urticaria: Real-life experiences of 280 patients. J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1743-1745. doi: 10.1016/j.jaip.2017.08.035. Epub 2017 Oct 4. PubMed PMID: 28988786.

15: Vadasz Z, Elbirt D, Radian S, Bezalel-Rosenberg S, Mahlab-Guri K, Toubi E, Asher I, Sthoeger Z. Low levels of the immunoregulator Semaphorin 4D (CD100) in sera of HIV patients. Clin Immunol. 2018 Jun;191:88-93. doi: 10.1016/j.clim.2017.09.010. Epub 2017 Sep 14. PubMed PMID: 28917721.

16: Rimar D, Slobodin G, Rosner I, Rozenbaum M, Kaly L, Boulman N, Jiries N, Awisat A, Vadasz Z. [THE ROLE OF SEMAPHORIN 7A IN SYSTEMIC SCLEROSIS]. Harefuah.  2017 Jul;156(7):418-421. Hebrew. PubMed PMID: 28786275.

17: Cozacov R, Halasz K, Haj T, Vadasz Z. Semaphorin 3A: Is a key player in the pathogenesis of asthma. Clin Immunol. 2017 Nov;184:70-72. doi: 10.1016/j.clim.2017.05.011. Epub 2017 May 11. PubMed PMID: 28502680.

18: Kessel A, Lin C, Vadasz Z, Peri R, Eiza N, Berkowitz D. The association between semaphorin 3A levels and gluten-free diet in patients with celiac disease. Clin Immunol. 2017 Nov;184:73-76. doi: 10.1016/j.clim.2017.05.010. Epub  2017 May 11. PubMed PMID: 28502679.

19: Rimar D, Rosner I, Slobodin G, Rozenbaum M, Kaly L, Boulman N, Vadasz Z. Lysyl Oxidase in Systemic Sclerosis: Getting Under the Skin. Isr Med Assoc J. 2016 Sep;18(9):534-536. PubMed PMID: 28471599.

20: Kessel A, Graif Y, Vadasz Z, Schichter-Konfino V, Almog M, Cohen S, Teplitski V, Stein N, Baiardini I, Maurer M, Toubi E. Adaptation and Validation of the Israeli Version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL). Isr Med Assoc J. 2016 Aug;18(8):461-465. PubMed PMID: 28471576.

21: Rimar D, Rosner I, Slobodin G, Rozenbaum M, Halasz K, Jiries N, Kaly L, Boulman N, Vadasz Z. Semaphorin 3A, a potential immune regulator in familial Mediterranean fever. Clin Exp Rheumatol. 2016 Sep-Oct;34(6 Suppl 102):S52-S55. Epub 2016 Apr 21. PubMed PMID: 27157528.

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